Name KUMAGAI Yoshito
Position Professor
Affiliation Faculty of Medicine/Majors of Medical Sciences
Supervision Master/Doctor
Office
Email yk-em-tu@md.tsukuba.ac.jp
Telephone
Specializations Environmental Biology & Toxicology
Professional Experience 1989.4～1992.3 Postdoctoral Fellow (University of California Los Angeles, USA
1992.4～1994.11 Senior Scientist (National Institute for Environmental Studies, Japan)
1994.12～1998.12 Assistant Professor (University of Tsukuba)
1999.1～2003.11 Associate Professor
2003.12～ Professor
Research Topics Environmental chemicals, Health effect, Adaptive response, Cellular protection, Modification of cellular proteins
Publications 1. Kumagai Y, Shinkai Y, Miura T, Cho AK. The chemical biology of naphthoquinones and its environmental implications. Annual Review of Pharmacology and Toxicology 52: 221-247, 2012
2. Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y. GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate. Chemical Research in Toxicology 24: 1836-1844, 2011
3. Yoshida E, Toyama T, Shinkai Y, Sawa T, Akaike T, Kumagai Y. Detoxification of methylmercury by hydrogen sulfide producing enzyme in mammalian Cells. Chemical Research in Toxicology 24: 1633-1635, 2011
4. Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y. Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. Environmental Health Perspective 119: 1117-1121, 2011
5. 熊谷嘉人. ヒ素研究におけるフィールドサイエンスと実験科学の融合. YAKUGAKU ZASSHI, 129:1177-1185, 2009
6. 熊谷嘉人. 親電子シグナル伝達. 実験医学増刊号 27: 50-55, 2009
7. Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ,Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. Free Radical Biology & Medicine 44: 1645-1655, 2008
8. Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y. Chemical knockdown of protein tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. Journal of Biological Chemistry 282: 33396-33404, 2007
9. Kumagai Y, Sumi D. Arsenic: Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity. Annual Review of Pharmacology and Toxicology 47: 243-262, 2007
10. Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, Van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T. Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Nature Chemical Biology 8: 714-724, 2012.
Courses at MES/DSES Introduction to Environmental Symbiotic Studies, Environmental Health Perspective
Courses at Other Programs Environmental Health Perspective
Lecture in Environmental Health Perspective
Dissertation in Medical Sciences
Seminar in Environmental Health Perspective
Laboratory in Environmental Health Perspective
International practical medical science
Advanced Seminar in Medical Sciences
TRIOS http://www.trios.tsukuba.ac.jp/Profiles/0009/0001298/prof_e.html
Lab Environmental Biology
Lab URL http://www.md.tsukuba.ac.jp/environmental_medicine/index.html
Private Web 基盤研究（S）http://www.md.tsukuba.ac.jp/environmental_medicine/kibanS/index.html
Private Web URL