Name SHINKAI Yasuhiro
Position Associate Professor
Affiliation Faculty of Medicine/Majors of Medical Sciences
Supervision Master/Doctor
Office
Email ya_shinkai@md.tsukuba.ac.jp
Telephone
Specializations Environmental Pharmaceutical Science
Professional Experience 2001.3　Graduated from Faculty of Engineering, University of Toyama
2003.3　Graduated from Master’s Program in Environmental Sciences,University of Tsukuba
2007.3 Graduated from Doctoral Program in Graduate School of Comprehensive Human Sciences, University of Tsukuba
2007.4 Research Fellow, Academic Frontier, Hokuriku University
2009.10 Assistant Professor, Institute of Community Medicine, University of Tsukuba
2019.6 Associate Professor, Faculty of Medicine/Majors of Medical Sciences, University of Tsukuba
Research Topics Cellular defense mechanisms against chemicals
Publications Shinaki Y, Masuda A, Akiyama M, Xian M, Kumagai Y. Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides. Toxicolgical Sciences. 2017; 156: 412-421.

Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T. Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells. Toxicology and Applied Pharmacology. 2016; 295: 37-46.

Shinkai Y, Nishihara Y, Amamiya M, Wakayama T, Li S, Kikuch T, Nakai Y, Shimojo N, Kumagai Y. NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals. Free Radical Biology and Medicine. 2016; 91: 178-187.

Shinkai Y, Li S, Kikuchi T, Kumagai Y. Participation of metabolic activation of 2,4,6-trinitrotoluene to 4-hydroxylamino-2,6-dinitrotoluene in the hematotoxicity. Journal of Toxicological Sciences. 2015; 40: 597-604.

Shinkai Y, Li S, Kikuchi T, Shimojo N, Kumagai Y. Health survey of workers in a 2,4,6-trinitrotoluene explosives factory in Fuxin, China. Fundamental Toxicological Sciences. 2015; 2: 171-175.

Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y. Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress. Chemical Research in Toxicology. 2015; 28: 838-847.

Shinkai Y, Nakajima S, Eiguren-Fernandez A, Stefano ED, Schmitz DA, Froines JR, Cho AK, Kumagai Y. Ambient vapor samples activate the Nrf2-ARE pathway in human bronchial epithelial BEAS-2B cells. Environmental Toxicology 2014; 29: 1292-1300.

Shinkai Y, Yamanaka I, Duong HHT, Quynh NT, Kanaho Y, Kumagai Y. Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells. Journal of Toxicological Sciences 2013; 38: 875-878.

Shinkai Y. Kaji T. Cellular defense mechanisms against lead toxicity in the vascular system. Biological Pharmaceutical Bulletin 2012; 35:1885-1891.

Shinkai Y, Iwamoto N, Miura T, Ishii T, Cho AK, Kumagai Y. Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling. Chemical Research in Toxicology 2012; 25: 1222-1230.

その他　原著・総説 37編

http://www.trios.tsukuba.ac.jp/Profiles/0009/0006824/theses_e1.html
Courses at MES/DSES Environmental Health Perspective
Introduction to Environmental Symbiotic Studies
Special Exercise of Sustainable Environmental Studies I(A)[English class]
Special Exercise of Sustainable Environmental Studies II(A)[English class]
Special Exercise of Sustainable Environmental Studies III(A)[English class]
Special Exercise of Sustainable Environmental Studies I(B)[English class]
Special Exercise of Sustainable Environmental Studies II(B)[English class]
Special Exercise of Sustainable Environmental Studies III(B)[English class]
Special Exercise of Sustainable Environmental Studies I(C)[English class]
Special Exercise of Sustainable Environmental Studies II(C)[English class]
Special Exercise of Sustainable Environmental Studies III(C)[English class]
Courses at Other Programs Environmental Toxicology
Internship I
Internship II
Internship III
Internship IV
Dissertation in Medical Science
Seminar on Basic Medical Sciences
TRIOS http://www.trios.tsukuba.ac.jp/Profiles/0009/0006824/prof_e.html
Lab Environmental Biology
Lab URL http://www.md.tsukuba.ac.jp/environmental_medicine/index.html
Private Web
Private Web URL http://www.md.tsukuba.ac.jp/chs/life_system/shinkai.htm